Daniel 7:6

Some of the historians recorded that these ruled two hundred forty-five years until Darius the chief, whom Alexander of Macedon deposed in the seventh year and transferred the kingdom of the Persians to the Greeks. Just as also Daniel says, "After this I was looking, and behold, another beast like a leopard and four wings of a bird were upon it and four heads were on the beast, and authority was given to it." [Daniel 7:6] And so having named a leopard, he signals the kingdom of the Greeks, which Alexander of Macedon began, and he compares them to a leopard on account of them being sharp in mind and resourceful in reasoning and relentless in heart, in which manner also the spotted creature is the model of the kingdom of the Greeks, quick to do evil and quick to drink the blood of men. He says, "Four wings of a bird were upon it and four heads were on the beast." [Daniel 7:6] For after the kingdom of Alexander was lifted up and grew in strength and was named in all the world, his kingdom was divided to his four chiefs. For while dying, Alexander distributed it to his companions who were of his race, four men, Seleucus, Demetrius, Ptolemy, and Philip, and these all put on crowns, just as Daniel predicts and was recorded in the first book of the Maccabees. [1 Maccabees 1:9]

These words concern the kingdom of the Persians. Indeed, what in the statue of Nebuchadnezzar had been indicated under the aspect of bronze, a very hard metal, here is seen under the image of the leopard, an extremely agile and harmful beast. [The beast] is …

The "four heads" refer to the division of the empire that took place after Alexander. Four kings were established instead of one. The rulership of Egypt was entrusted to Ptolemy, son of Lagos; the realm of the Orient was granted to Seleucus; Antigonus acquired Asia; …

1. In speaking of a "lioness from the sea," he meant the rising of the kingdom of Babylon, and that this was the "golden head of the image." And in speaking of its "eagle wings," be meant that king Nebuchadnezzar was exalted and that his glory was lifted up against God. Then he says "its wings were plucked off," i.e., that his glory was destroyed; for he was driven out of his kingdom. And the words, "A man's heart was given it, and it was made stand upon the feet of a man," mean that he came to himself again, and recognised that he was but a man, and gave the glory to God. Then after the lioness he sees a second beast, "like a bear," which signified the Persians. For after the Babylonians the Persians obtained the power. And in saying that "it had three ribs in its mouth," he pointed to the three nations, Persians, Medes, and Babylonians, which were expressed in the image by the silver after the gold. Then comes the third beast, "a leopard," which means the Greeks; for after the Persians, Alexander of Macedon had the power, when Darius was overthrown, which was also indicated by the brass in the image. And in saying that the beast "had four wings of a fowl, and four heads," he showed most clearly how the kingdom of Alexander was parted into four divisions. For in speaking of four heads, he meant the four kings that arose out of it. For Alexander, when dying, divided his kingdom into four parts. Then he says, "The fourth beast (was) dreadful and terrible: it had iron teeth, and claws of brass." Who, then, are meant by this but the Romans, whose kingdom, the kingdom that still stands, is expressed by the iron? "for," says he, "its legs are of iron." 2. After this, then, what remains, beloved, but the toes of the feet of the image, in which "part shall be of iron and part of clay mixed together? […]

After other victories, he turned aside to visit Jerusalem. The next verse is also supposed to predict his conquests; and the facts detailed by Rycault, volume 1, pages 246-248, respecting the conquest of Judea, Arabia, and Egypt, at the commencement of the sixteenth century of the Christian era., are asserted to fulfill Daniel 11:41 to 43.