Isaiah 21:4

(Verse 3, 4.) Therefore my loins are filled with pain: anguish has taken hold of me, like the anguish of a woman in labor: I am bowed down when I hear it, I am troubled when I see it. My heart is faint, darkness has overwhelmed me. Babylon, my beloved, has become a wonder to me. The prophets are therefore obscured, because many individuals are changed in them.

[Daniel 5:30-31] "On that same night Belshazzar, King of the Chaldeans, was slain, and Darius the Mede succeeded to his kingdom at the age of sixty-two." Josephus writes in his tenth book of the Jewish Antiquities that when Babylon had been laid under siege by the Medes and Persians, that is, by Darius and Cyrus, Belshazzar, King of Babylon, fell into such forgetfulness of his own situation as to put on his celebrated banquet and drink from the vessels of the Temple, and even while he was besieged he found leisure for banqueting. From this circumstance the historical account could arise, that he was captured and slaughtered on the same night, while everyone was either terrified by fear of the vision and its interpretation, or else taken up with festivity and drunken banqueting. As for the fact that while Cyrus, King of the Persians, was the victor, and Darius was only King of the Medes, it was Darius who was recorded to have succeeded to the throne of Babylon, this was an arrangement occasioned by factors of age, family relationship, and the territory ruled over. By this I mean that Darius was sixty-two years old, and that, according to what we read, the kingdom of the Medes was more sizable than that of the Persians, and being Cyrus's uncle, he naturally had a prior claim, and ought to have been accounted as successor to the rule of Babylon. Therefore also in a vision of Isaiah which was recited against Babylon, after many other matters too lengthy to mention, an account is given of these things which are to take place: "Behold I Myself will rouse up against them the Medes, a people who do not seek after silver nor desire gold, but who slay the very children with their arrows and have no compassion upon women who suckle their young" (Isaiah 13:17-18). […]

Second, as to the affections: my heart, that is, the affections, failed, in sadness: my bowels are in pain (Jer 4:19). Third, as to astounded understanding: darkness, that is, the troubles I have foreseen, amazed me, as if I were in darkness: every one that …

My heart panted,....

Let this give an effectual check to vain mirth and sensual pleasures, and forbid us ever to lay the reins on the neck of them--that we know not what heaviness the mirth may end in, nor how soon laughter may be turned into mourning; but this we know that for all these things God shall bring us into judgment; let us therefore mix trembling always with our joys.